Which statement is NOT a component of membranous nephropathy treatment?

Which statement is NOT a component of membranous nephropathy treatment?

• A. Exclude underlying causes
• B. RAAS inhibitors
• C. Prednisone plus another immunosuppressant
• D. Prednisone alone

Answer: (D)

Membranous nephropathy treatment centers on reducing proteinuria and protecting kidney function, which involves several practical steps. If a secondary cause is present, identifying and addressing that cause is important. Using RAAS inhibitors helps control blood pressure and lessen proteinuria, improving outcomes. For patients with nephrotic-range proteinuria or persistent disease, immunosuppressive therapy is used, typically as a combination regimen that includes steroids plus another immunosuppressant (such as cyclophosphamide or a calcineurin inhibitor). Prednisone alone is not a standard approach. Evidence supports combining a steroid with another immunosuppressant or opting for conservative management with RAAS blockade, rather than relying on prednisone by itself. Hence, prednisone alone is not considered a component of typical membranous nephropathy treatment.

Membranous nephropathy treatment centers on reducing proteinuria and protecting kidney function, which involves several practical steps. If a secondary cause is present, identifying and addressing that cause is important. Using RAAS inhibitors helps control blood pressure and lessen proteinuria, improving outcomes. For patients with nephrotic-range proteinuria or persistent disease, immunosuppressive therapy is used, typically as a combination regimen that includes steroids plus another immunosuppressant (such as cyclophosphamide or a calcineurin inhibitor).

Prednisone alone is not a standard approach. Evidence supports combining a steroid with another immunosuppressant or opting for conservative management with RAAS blockade, rather than relying on prednisone by itself. Hence, prednisone alone is not considered a component of typical membranous nephropathy treatment.